Research and Information
Dr Wan Teh - Gynaecologist & Fertility Specialist (melbourne IVF)
Dr Teh has ongoing research involvement. Under the National Health and Medical Research Council (NHMRC) scholarship, she is investigating the determinants of uterine receptivity in women with implantation failure. What this means for women
looking to conceive, Dr Teh aims to optimize the rates of success for pregnancy establishment.
Pregnancy occurs when an embryo (fertilized egg) attaches to the endometrium (lining of the womb). Successful establishment of pregnancy requires a healthy embryo, a uterus which is in a state that can accept the embryo (uterine receptivity), and a synchronized development of the embryo and the endometrium. This happens at a particular time of the woman’s menstrual cycle. If the growth and development of an embryo is not matched with the stage of the woman’s cycle (embryo-endometrial asynchrony), such that the endometrium can accept the embryo, then implantation or pregnancy may not occur. The following diagram demonstrates the role of embryo-endometrial synchrony in successful implantation.
Where indicated for patients, Dr Teh utilizes the Endometrial Receptivity Array (ERA) test, and/or performs Endometrial Stimulation (“scratch”) procedure to improve uterine receptivity and pregnancy conception rate.Endometrial Receptivity Array (ERA)
Endometrial Receptivity Array (ERA) is a personalized genetic test to diagnose the state of endometrial receptivity in women. This test is recommended for women who have had recurrent implantation failure with good embryos, who may be suffering from embryo-endometrial asynchrony.Endometrial stimulation (‘scratch’)
Studies have suggested that mechanical stimulation to the endometrium (lining of the womb) may improve uterine receptivity, therefore improve implantation and pregnancy rate. Mechanical stimulation to the endometrium can be induced by pipelle endometrial biopsy or hysteroscopy and curette.
Latest research paper (‘The final publication is available at link.springer.com’)
Scientific papers published by Dr Teh:
- What is the contribution of embryo-endometrial asynchrony to implantation failure? Teh WT, McBain J, Rogers P. J Assisted Reproduction and Genetics. Epub 2016 Aug.
- Endometrial vezatin and its association with endometriosis risk. Holdsworth-Carson SJ, Fung JN, Luong HT, Sapkota Y, Bowdler LM, Wallace L, Teh WT, Powell JE, Girling JE, Healey M, Montgomery GW, Rogers PA. Human Reproduction. 2016 May;31(5):999-1013.
- The impact of uterine radiation on subsequent fertility and pregnancy outcomes. Teh WT, Stern C, Chander S, Hickey M. Biomed Research International. 2014;2014:482968.
- Quantifying circulating hypoxia-induced RNA transcripts in maternal blood to determine in utero fetal hypoxic status. Whitehead C, Teh WT, Walker SP, Leung C, Mendis S, Larmour L, Tong S. BMC Med. 2013 Dec 9;11:256.
- Circulating MicroRNAs in maternal blood as potential biomarkers for fetal hypoxia in-utero. Whitehead CL, Teh WT, Walker SP, Leung C, Larmour L, Tong S. PLoS One. 2013 Nov 25;8(11):e78487.
- Gestational diabetes: development of an early risk prediction tool to facilitate opportunities for preven tion. Teede HJ, Harrison CL, Teh WT, Paul E, Allan CA. Australian and New Zealand Journal of Obstetrics & Gynaecology. 2011 Dec;51(6):499-504.
- Risk factors for gestational diabetes mellitus: implications for the application of screening guidelines. Teh WT, Teede HJ, Paul E, Harrison CL, Wallace EM, Allan C. Australian and New Zealand Journal of Obstetrics & Gynaecology. 2011 Feb;51(1):26-30.
- Umbilical endometriosis, a pathology that a gynecologist may encounter when inserting the Veres needle. Teh WT, Vollenhoven B, Harris PI. Fertility & Sterility. 2006 Dec;86(6):1764.e1-2.